New research suggests two cannabinoids have opposing effects on SARS-CoV-2 - Goketogenics | All About Ketogenic Diet -

New research suggests two cannabinoids have opposing effects on SARS-CoV-2


A new study indicates that two cannabinoids have opposing effects on SARS-CoV-2 (SARS-associated coronavirus 2). The virus is responsible for causing SARS (severe acute respiratory syndrome). For those not familiar with this term, SARS is a contagious respiratory disease that started in China. And also, spread to several other countries in 2003, infecting 8098 people and killing 774. The fatality rate was 9% among people infected by SARS-CoV-2. Although the condition is usually resolved within 2 weeks of being admitted to the hospital.

Cannabinoids suppress SARS

Scientists from Italy’s National Institute of Infectious Diseases showed that cannabidiol and tetrahydrocannabinol suppress replication of SARS-CoV in infected cells by different mechanisms. This may explain they’re apparent ability to relieve symptoms of severe acute respiratory syndrome. The work was published online ahead of print in Antiviral Research. Both cannabinoids are thought to interact with receptors known as CB1 and CB2. But, whether they actually do so remains to be determined.

CB1 and CB2 receptors act against each other

CB1 and CB2 receptors are located throughout our body. The CB1 receptor is one of many G protein-coupled receptors that, when activated, binds to a chemical messenger called an agonist, triggering a chain reaction that leads to changes in cell behaviour. Anandamide is believed to be a natural ligand for CB1 receptors – which could explain its psychoactive properties.

CB1 receptor suppresses the immune response

Research presented at IDWeek has demonstrated exposure to cannabidiol (CBD). A non-psychoactive compound in cannabis can block an immune response to a virus. It is known as severe acute respiratory syndrome coronavirus (SARS-CoV). The study showed that CBD could be of therapeutic value in treating infections caused by SARS-CoV. Also, the explained study coauthor Karin McKenzie, Ph.D., from The Scripps Research Institute.

Our bodies are capable of producing cannabinoids

chemicals that can fight disease and reduce inflammation. But our systems are particularly good at producing one cannabinoid, in particular, known as 2-AG (short for 2 -arachidonoylglycerol). Which plays a role in slowing down diseases like Systemic Acquired Resistance Syndrome (SARS). Therefore, researchers from Canada’s McMaster University found in their new study that two different cannabinoids actually play roles in fighting off SARS.

The endocannabinoid system protects us from infections

A new study published in The Journal of Immunology has confirmed what many people already know. There is a connection between our immune system and our endocannabinoid system. So, In addition to regulating processes like sleep, pain, and appetite. It turns out that endocannabinoids play an important role in our body’s response to infection. Cannabinoids are plant compounds found within cannabis plants; So, they have little to no psychoactive properties but are being studied for their medicinal benefits.

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